Evaluation of anti-inflammatory, cough relief and expectorant effects of Khai thau - BT extraction through practical experiments

Abstract

Drug Khai thau - BT for treatment of acute inflammation, cough, sputum is a folk remedy, the composition of which is completely from the Vietnam traditional herbs has been applied in clinical treatment for patients since 1998. Objectives: To evaluate the anti-inflammatory, cough relief, and expectorant effects of Khai thau - BT extraction in the practical experiment. Methods: The anti-inflammatory effect was investigated using carrageenan on white rat carnivores. The cough relief and expectorant effects were evaluated on 40 white mice randomly divided into 4 plots, each with 10 mice. Results: The Khai thau - BT dose at 9.6 ml/kg/day had a high anti-inflammatory effect at the point of 6 hours and 24 hours and a good expectorant effect on the experimental model, and it helped to extend the duration between two coughing occurences in mice caused by ammonia. Conclusion: Khai thau - BT extract has the anti-inflammatory effect in white mice at the dose of 9.6 ml/kg and the cough relief effect at 7.2 ml/kg and 21.6 ml/kg in white mice. Khai thau - BT extract’s cough relief effect was equivalent to codeine at the dose of 20 mg/kg.