Study on the association of DNAH1 rs12163565 with male infertility in Vietnamese individuals

Abstract

Male infertility is a disease that affects men’s fertility caused by various factors including genetic abnormalities, and immunological or endocrine diseases. Several studies have demonstrated the correlation between DNAH1 polymorphisms and the risk of having male infertility. To assess the association of DNAH1 rs12163565 with male infertility, we extracted total DNA from whole blood of 213 Vietnameses, including 110 patients with male infertility and 103 healthy controls. The genotypes of the polymorphism were determined by PCR-RFLP method. The distribution of genotypes and their relationship with male infertility were analyzed by statistical methods. The results indicated that DNAH1 rs12163565 followed Hardy-Weinberg equilibrium (p>0.05). However, no association was established between the polymorphism and male infertility in the three models (additive, dominant, and recessive) (p>0.05). This study would provide the knowledge about the association of DNAH1 with male infertility in Vietnamese population.