Chemical composition and biological activity of leaf extracts of Adinandra bockiana E. Pritz. ex Diels

Abstract

Adinandra bockiana E. Pritz. ex Diels collected in Lao Cai province, Vietnam belongs to the Adinandra genus. Some species of the genus Adinandra have been studied for their
botanical characteristics and bioactive compounds, however, A. bockiana has not been studied to date. Therefore, studying the chemical composition and biological activity of A. bockiana leaf extracts is pioneering and necessary in reality. The leaf extracts of A. bockiana have been quantified and determined to contain tannins, coumarins and polyphenolic compounds. The ethanol extract, dichloromethane extract and ethyl acetate extract at the concentrations 20, 60, and 200 µg/ml can inhibit the growth of B. subtilis, L. plantarum, and S. marcescens. The ethanol extract, dichloromethane extract
and ethyl acetate extract have free radical reduction activity, which EC₅₀ values reached 0.2, 0.47, and 5.7µg/ml, respectively. The ethanol extract exhibited inhibitory activities on gastric, lung, and breast cancer cell lines with IC₅₀ values of 58.62, 48.73, and 43.15 µg/ml, respectively. The results show that A. bockianais a potential plant that contains many compounds that have antibacterial, antioxidant, and anticancer activities.