Prevalence of ESBL-producing bacteria on healthy people in Trang An commune, Binh Luc district, Ha Nam province

Abstract

The cross-sectional study aimed to describe the status of extended-spectrum beta-lactamases (ESBL)-producing bacteria isolated from stool samples of healthy people in Trang An commune, Binh Luc district, Ha Nam province in 2018. A total of 94 samples were cultured on MacConkey agar containing 2 µg/ml ceftazidime for evaluating the growth of drug-resistant strains and the rate of bacteria carrying ESBL-encoding genes. The results showed that: (1) the proportion of ESBL-producing bacteria were found very high in the participants (99%); nevertheless, the levels of antibiotic resistance were associated with the rate of bacterial growth; (2) the TEM was the most prevalent ESBLencoding gene (85.1%), followed by CTX-M (71.3%) and SHV (5.3%). These results exhibited that the status of ESBL-producing bacteria was very serious in the Trang An population. Therefore, it is essential to monitor the antibiotic resistance in this region as well as other regions for the long-term development strategy to prevent the emergence and spread of antibiotic-resistant bacteria.