Formulation of foamable emulsion containing (Sesamum indicum L. oil, (Eclipta prostrata (L) L. extract, and (Carthamus tinctorius L.)

Abstract

The objectives of the study were to formulate a foamable emulsion containing black sesame (sesamum indicum L.) oil, Carthamus tinctorius L. extract, and Eclipta prostrata (L) L. extract and to evaluate its hair growth promoting activity in vivo. The base formulation of the foamable emulsion was established based on the ratio of each foaming agent (sodium lauryl sulfate: cocamidopropyl betaine) in the mixture, type of emulsifier, and concentration of the emulsifier. The quality criteria of the final foamable emulsion such as appearance, pH, emulsion density, foam density, physical stability, and identification were evaluated. The Swiss albino mice were used for evaluating the hair growth stimulation activity of the final foamable emulsion. The results showed that the chosen ratio of sodium lauryl sulfate and cocamidopropyl betaine was 1:1. The emulsifier was Cremophor RH 40 with the concentration of 10%. The formulated foamable emulsion containing black sesame oil, Carthamus tinctorius L. extract, and Eclipta prostrata (L) L. extract has dark brown colour, herbal extract flavour, pH of 5.2, emulsion density of 1.06, foam density of 0.108 g/cm3, suitable physical stability, and positive reaction with FeCl3 solution. The in vivo hair growth stimulation activity of the foamable emulsion showed no significant difference as compared to that of the control group. In conclusion, the formulation of foamable black sesame oil emulsion containing Carthamus tinctorius L. and Eclipta prostrata (L) L. extracts was successfully established and could be applied for promoting hair growth in human.