A study on preparing solid dispersion system of Felodipine by spray drying method

Abstract

In this study, the authors succeeded in preparing the solid dispersion system of Folodipine (FDP) which improves the solubility and dissolution. The influence of hydrophilic carriers including PVP K30, HPMC E5LV, Poloxamer and mannitol on the solubility and dissolution rate of FDP solid dispersion system (SDS) was also studied. In addition, Poloxamer was used as surfactant in FDP SDS, and effect of Poloxamer on the improvement of solubility and dissolution of FDP was also assessed. Finally, the formula of FDP SDS with (PVP K30:mannitol:Poloxamer:FDP) = (9:2:0.629:0.9313) was chosen. The solubility of FDP from SDS was 2.1 times higher than that of raw material FDP. The dissolution of FDP from SDS was also improved, FDP was released and dissolved more quickly and higher than raw material FDP. This SDS could be applied for dosage form of FDP to improve the bioability of the drug.