Evaluation of inhibitory effects of Vietnamese medicinal plant extracts on Helicobacter pylori

Abstract

Ethyl acetate and methanol extracts of 30 Vietnamese medicinal plants with dry weight contents ranging around 3.43-35.29% were evaluated for the inhibition ability on Helicobacter pylori (HP). Analyses regarding the presence of three previously identified anti-HP compounds including quercetin, berberine and glycyrrhizic acid by thin layer chromatography indicated that berberine was the most common compound (20/30 plants). Ten of these 30 plants showed anti-HP activities, with inhibition zones from 12 to 42 cm, 8 of which contained berberine, and 7 of which comprised quercetin. Two plants, wild-bean and Piper betle showed significant activities against HP; therefore, they were identified to be further extracted and isolated to find potential compounds for HP inhibitory effect.