Nghiên cứu bào chế Liposome Amphotericin B

Abstract

Liposome is prepared by two methods: thin film hydration and ethanol dilution with main ingredients including Amphotericin B (AmB), hydrogenated soybean phosphatidylcholine, distearoyl phosphatidylglycerol and cholesterol. By investigating and selecting, some factors belonging to formula and pharmaceutical procedure have been achieved. The result is that a suspension of Liposome AmB which is prepared has a small dimension (of about 200 nm), consistent distribution (PDI < 0.2) and high percentage of entrapment of Liposome (above 70%).