Study on synthesis of tenofovir disoproxil fumarate

Abstract

Tenofovir disoproxil fumarate (Viread^®) is an antiretroviral agent acting under the inhibition mechanism of reverse transcriptase, an important enzyme for the growth of human immunodeficiency virus (HIV) and hepatitis B virus. In this article, the synthesis of tenofovir disoproxil fumarate from adenine through five steps with a good yield is reported. The synthesis process is simple and applicable on a larger scale.