USING EXPERIMENTAL PLANNING METHOD TO PREPARE SUSTAINED-RELEASE FELODIPINE TABLETS WITH HYDROPHILIC MATRIX

Abstract

This study used the experimental planning method to design the formula of sustained-release felodipine tablets. The process was optimized by taking the influences of the chosen excipients, including HPMC E4M, HPMC E15LV, on the drug release of the formulated tablets as the independent variables. Three dependent variables were the dissolubility percentage of felodipine release at the sampling times of 2 hs, 6 hs, 10 hs (Y₂, Y₆, Y₁₀ respectively). The release profile of felodipine from the optimized formula almost met the predicted release profile and was similar to that of the reference tablets. The kinetics of drug release from the optimized tablets and reference tablets also complied with the Korsmeyer - Peppas model.