Evaluation of the relationship between morphological blastocyst and chromosome abnormality

Abstract

Conducting research on the relationship between blastocyst’s morphology and chromosome abnormality by retrospective and cross-sectional description studies in 953 embryos on day 5 analysed for preimplantation genetic screening (PGS) at assisted reproductive technology center, 16A Ha Dong General Hospital from February 2018 to May 2019 exhibited that the rates of mosaic, numerical abnormality and structural abnormality were 56.68%, 36.65%, and 6.67%, respectively. The number of normal blastocyst accounted for the majority in good morphological embryo group (69.1%). The incidence of 1, 2 or 3 chromosome abnormalities per embryo increased gradually in the medium and bad morphology embryos group. A higher proportion of chromosome abnormality was found in association with low expansion degree, ICM C and TE C. The top quality morphology of day 5 embryo was found in association with the decreasing risk of chromosome abnormality (p<0.001, OR=0.22, CI95%=0.16-0.29). In conclusion, there was a significant relationship between morphological blastocyst and chromosome abnormality. The low expansion degree, TE C, ICM C, and poor quality morphological blastocyst associated with an increase in the rate of chromosome abnormality.