Analysis of EGFR mutations in paraffin-covered tissue samples and some related factors from non-small cell lung cancer patients over 60 years old

Abstract

Objective: to describe EGFR mutation status detected in tissue samples and analyse some related factors
in NSCLC patients over 60 years old. Methodology:
detecting EGFR mutations by Strip Assay Kit from
351 tissue samples of NSCLC patients at Bach Mai
Hospital 2017-2018. Results: ratio of EGFR is 38.2%,
including exon 19 deletion mutation (48.6%), exon 21
point mutation (41.6%), exon 18 point mutation (4.9%),
and T790M resistant mutation on exon 20 (4.9%).
The mutant rate in females (66.7%) is higher than in
males (27.5%), and shows a higher rate in non-smokers
(53.3%) compared to smokers (30.3%). Conclusions: the
EGFR mutation ratio in NSCLC patients over 60 years
is relatively high, the frequent mutant sites are exon 19
and 21. Mutations are more common in women and nonsmokers. The maxSUV value of primary lung tumors in
patients with gene mutations is lower than in the nonmutant group.