Antibiotic resistantce charateristics and genotype correlation of serratia marcescens strains isolated in patients treated at 108 Central Military Hospital

Abstract

The study was conducted to describe antibiotic resistance characteristics and genotype correlation of 25 Serratia marcescens strains isolated in patients treated at 108 Central Military Hospital from 2014-2016. The results showed that there was an increase in antibiotic resistance of Serratia marcescens strains in this study for antibiotic groups such as fluoroquinolones, aminoglycosides, and extended-spectrum cephalosporins, which were commonly used for treatment of Serratia marcescens infection. The rates of resistance to cefotaxime (32%), ciprofloxacin (28%), gentamycin (24%), aztreonam (28%) and cefepime (12%) were higher than previous studies in the world such as in the US and Europe. Tweenty percent of Serratia marcescens isolates capable of producing ESBL carried bla CTX-M gene and 12% carried bla TEM gene. Analysis on genotype correlation by Pulsed-field gel electrophoresis (PFGE) technique showed that strains of the bacterium did not belong to a single genotype, there were three genotypes S1, S2, S3 identified with similarity of ≥85%, and the possible hypothesis about the spread of bacterial infections between departments in the hospital existed.