A study on preparation of 18F-Choline radiopharmaceutical at 108 Military Central Hospital

Authors

  • Thanh Quang Vu*, Ngoc Khoan Ha, Thanh Rin Bui, Trung Dung Nguyen, Tuan Linh Pham
  • Thi Thu Hien Doan

Keywords:

18F-Choline, 18F-FCH, hepatocellular carcinoma, PET/CT, prostate cancer

Abstract

18F-Choline (18F-FCH) radiopharmaceutical is used in PET, PET/CT scans to diagnose prostate cancer (PC) and hepatocellular carcinoma (HCC). Currently, this radiopharmaceutical is not available in Vietnam. Because the physical half-life of Flo-18 is only 110 minutes then 18F-FCH radiopharmaceutical cannot be imported from abroad. Therefore, the only option to have this radiopharmaceutical for clinical research and diagnosis is domestically produced. The purpose of the research is to prepare 18F-FCH to meet the 2017 European Pharmacopoeia standards (EuPh2017). The method of preparing 18F-FCH is carried out on an automatically controlled radiochemical synthesis module. The experimental results confirm that the total time of the synthesis of an 18F-FCH batch is 40±2 min. Synthesis yield is 15±5% after decay correction. Radiochemical purity is more than 99.9% that meets the requirements of EuPh2017 for PET radiopharmaceutical.

Classification number

2.6

Author Biographies

Thanh Quang Vu*, Ngoc Khoan Ha, Thanh Rin Bui, Trung Dung Nguyen, Tuan Linh Pham

108 Military Central Hospital

Thi Thu Hien Doan

Institute for Technology of Radioactive and Rare Elements

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Published

2020-11-30

Received 18 May 2020; accepted 8 July 2020

How to Cite

Vu Thanh Quang*, Ha Ngoc Khoan, Bui Thanh Rin, Nguyen Trung Dung, Pham Tuan Linh, & Doan Thi Thu Hien. (2020). A study on preparation of 18F-Choline radiopharmaceutical at 108 Military Central Hospital . Version B of Vietnam Journal of Science and Technology, 62(11). Retrieved from https://b.vjst.vn/index.php/ban_b/article/view/877

Issue

Vol. 62 No. 11 (2020): Volume 62 - Number 11 - November 2020

Section

Engineering and Technology

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