Preparation of SMEDDS to improve the stability of schaftoside from Desmodium styracifolium (Osb.) extract

Abstract

a SMEDDS containing Desmodium styracifolium (Osb.) extract (SMEDDS-DSE) is prepared to improve the stability of schaftosid. The chosen SMEDDS-DSE formulation contained DSE (30%, w/w) including isopropyl myristate (35%, w/w), tween 80 (45%, w/w) and PEG 400 (20%, w/w). The SMEDDS-DSE was dark brown and homogenous. The average particle size was 75.47±1.46 nm; the polydispersity index (PdI) was 0.24±0.02; and the average zeta potential value was -8.03±0.45 mV. The stability of schaftoside was studied at 37±2o C in different pH values (pH 1.2 for 2 hours, pH 6.8 for 6 hours, and pH 7.4 for 8 hours). The results showed that the stability of schaftosid was improved significantly by SMEDDS-DSE. The applications of SMEDDS-DSE as a drug delivery system were potential.