Microwave-assisted synthesis of 4,6-dihydroxyaurone derivatives

Authors

  • Thi Cam Van Vo*, Quoc Manh Dao, Hoang Minh Vo, Hoang Phuc Tran, Nguyen Hoai Phuong Huynh

Keywords:

aurone, benzaldehyde, microwave-assisted synthesis, phloroglucinol, 4,6-dihydroxyaurone

Abstract

In this study, the authors described the evaluation of microwave-assisted reaction conditions for the synthesis of 4,6-dihydroxyaurone derivatives, including synthesis of 2’,4’,6’-trihydroxychloroacetophenone (50 W, 65°C and 30 min); synthesis of 4,6-dihydroxybenzofuran-3(2H)-one (50 W, 60°C and 5 min), and synthesis of 4,6-dihydroxyaurone (50 W, 80°C and 20-40 min).
The optimum procedure was applied to prepare 4,6-dihydroxyaurone derivatives with different
substituents on the benzylidene ring.

DOI:

https://doi.org/10.31276/VJST.65(2).18-22

Classification number

3.4

Author Biography

Thi Cam Van Vo*, Quoc Manh Dao, Hoang Minh Vo, Hoang Phuc Tran, Nguyen Hoai Phuong Huynh

Department of Medicinal Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, 41 Dinh Tien Hoang Street, Ben Nghe Ward, District 1, Ho Chi Minh City, Vietnam

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Published

2023-02-25

Received 6 July 2022; accepted 12 August 2022

How to Cite

Vo Thi Cam Van*, Dao Quoc Manh, Vo Hoang Minh, Tran Hoang Phuc, Huynh Nguyen Hoai Phuong. (2023). Microwave-assisted synthesis of 4,6-dihydroxyaurone derivatives. Version B of Vietnam Journal of Science and Technology, 65(2). https://doi.org/10.31276/VJST.65(2).18-22

Issue

Vol. 65 No. 2 (2023): Volume 65 - Number 2 - February 2023

Section

Medical and Pharmacological Sciences