Effectiveness of the treatment of liver cirrhosis by using bone marrow mesenchymal stem cell in a mouse model

Abstract

In the world, stem cell therapy has shown a potential in liver cirrhosis treatment. Up to now, we have not found out the best regimen of cell types, injection methods, while Vietnam has not yet published any result in this field. For that reason, this research aims to developing a new therapy for liver cirrhosis treatment in Vietnam. The authors conducted experiments using bone marrow mesenchymal stem cell for treatment in the mouse model with liver cirrhosis by CCl4 . The result showed that 21 days after injected 106 stem cells into tail vein, the treatment group was improved with the Albumin index from 1.753±0.042 to 2.116±0.120; the expression of genes related to fibrosis was decreased such as TGF (by 9 times), Procollagen (by 13 times), Integrin (by 3000 times); and the result also showed the reduction in the presence of collagen-1, SMA-α and the smaller fibrotic areas in histology compared with the control group.